Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined. Here we report through single-cell RNA-sequencing of diseased aort...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hadi, Tarik, Boytard, Ludovic, Silvestro, Michele, Alebrahim, Dornazsadat, Jacob, Samson, Feinstein, Jordyn, Barone, Krista, Spiro, Wes, Hutchison, Susan, Simon, Russell, Rateri, Debra, Pinet, Florence, Fenyo, David, Adelman, Mark, Moore, Kathryn J., Eltzschig, Holger K., Daugherty, Alan, Ramkhelawon, Bhama
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258757/
https://ncbi.nlm.nih.gov/pubmed/30479344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07495-1
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