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Pooled extracellular receptor-ligand interaction screening using CRISPR activation
Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-af...
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| Publié dans: | Genome Biol |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6258485/ https://ncbi.nlm.nih.gov/pubmed/30477585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1581-3 |
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