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Pooled extracellular receptor-ligand interaction screening using CRISPR activation

Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-af...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Chong, Zheng-Shan, Ohnishi, Shuhei, Yusa, Kosuke, Wright, Gavin J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258485/
https://ncbi.nlm.nih.gov/pubmed/30477585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-018-1581-3
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