An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression

BACKGROUND: Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression. The role of Hippo signalling effectors TAZ and YAP has never been addressed in...

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Pubblicato in:BMC Vet Res
Autori principali: Luu, Anita K., Schott, Courtney R., Jones, Robert, Poon, Andrew C., Golding, Brandon, Hamed, Roa’a, Deheshi, Benjamin, Mutsaers, Anthony, Wood, Geoffrey A., Viloria-Petit, Alicia M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258471/
https://ncbi.nlm.nih.gov/pubmed/30477496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12917-018-1651-5
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