Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium

Estrogen therapy increases the risk of ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. Both in vivo and in vitro, ovarian surface epithelial (OSE) cells exposed to estradiol develop a subpopulation that loses cell polarity, contact inhibition, and form...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Vuong, Nhung H., Cook, David P., Forrest, Laura A., Carter, Lauren E., Robineau-Charette, Pascale, Kofsky, Joshua M., Hodgkinson, Kendra M., Vanderhyden, Barbara C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258431/
https://ncbi.nlm.nih.gov/pubmed/30418965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007788
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