Single-cell RNA-sequencing reveals transcriptional dynamics of estrogen-induced dysplasia in the ovarian surface epithelium

Estrogen therapy increases the risk of ovarian cancer and exogenous estradiol accelerates the onset of ovarian cancer in mouse models. Both in vivo and in vitro, ovarian surface epithelial (OSE) cells exposed to estradiol develop a subpopulation that loses cell polarity, contact inhibition, and form...

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Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Vuong, Nhung H., Cook, David P., Forrest, Laura A., Carter, Lauren E., Robineau-Charette, Pascale, Kofsky, Joshua M., Hodgkinson, Kendra M., Vanderhyden, Barbara C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258431/
https://ncbi.nlm.nih.gov/pubmed/30418965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007788
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