Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence

We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photo-physical analysis, X-ray crystallography, and theoretical calculation, we show that fluorescence is t...

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Библиографические подробности
Опубликовано в: :J Am Chem Soc
Главные авторы: Liu, Yu, Wolstenholme, Charles H., Carter, Gregory C., Liu, Hongbin, Hu, Hang, Grainger, Leeann S., Miao, Kun, Fares, Matthew, Hoelzel, Conner A., Yennawar, Hemant P., Ning, Gang, Du, Manyu, Bai, Lu, Li, Xiaosong, Zhang, Xin
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258209/
https://ncbi.nlm.nih.gov/pubmed/29883112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02176
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