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Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence

We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photo-physical analysis, X-ray crystallography, and theoretical calculation, we show that fluorescence is t...

詳細記述

保存先:
書誌詳細
出版年:J Am Chem Soc
主要な著者: Liu, Yu, Wolstenholme, Charles H., Carter, Gregory C., Liu, Hongbin, Hu, Hang, Grainger, Leeann S., Miao, Kun, Fares, Matthew, Hoelzel, Conner A., Yennawar, Hemant P., Ning, Gang, Du, Manyu, Bai, Lu, Li, Xiaosong, Zhang, Xin
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258209/
https://ncbi.nlm.nih.gov/pubmed/29883112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02176
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