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Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence
We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photo-physical analysis, X-ray crystallography, and theoretical calculation, we show that fluorescence is t...
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6258209/ https://ncbi.nlm.nih.gov/pubmed/29883112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02176 |
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