Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence

We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photo-physical analysis, X-ray crystallography, and theoretical calculation, we show that fluorescence is t...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Liu, Yu, Wolstenholme, Charles H., Carter, Gregory C., Liu, Hongbin, Hu, Hang, Grainger, Leeann S., Miao, Kun, Fares, Matthew, Hoelzel, Conner A., Yennawar, Hemant P., Ning, Gang, Du, Manyu, Bai, Lu, Li, Xiaosong, Zhang, Xin
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258209/
https://ncbi.nlm.nih.gov/pubmed/29883112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02176
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