Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

BACKGROUND: Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER). Interfering with these m...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Salaroglio, Iris C., Gazzano, Elena, Abdullrahman, Ahmad, Mungo, Eleonora, Castella, Barbara, Abd-elrahman, Gamal Eldein Fathy Abd-ellatef, Massaia, Massimo, Donadelli, Massimo, Rubinstein, Menachem, Riganti, Chiara, Kopecka, Joanna
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258159/
https://ncbi.nlm.nih.gov/pubmed/30482226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0967-0
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