Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6

Head-to-tail polymers of sterile alpha motifs (SAM) can scaffold large macromolecular complexes. Several SAM-domain proteins that bind each other are mutated in patients with cystic kidneys or laterality defects, including the Ankyrin (ANK) and SAM domain-containing proteins ANKS6 and ANKS3, and the...

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Udgivet i:Structure
Main Authors: Rothé, Benjamin, Leettola, Catherine N., Leal-Esteban, Lucia, Cascio, Duilio, Fortier, Simon, Isenschmid, Manuela, Bowie, James U., Constam, Daniel B.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258031/
https://ncbi.nlm.nih.gov/pubmed/29290488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.12.002
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