Natural products as new antimitotic compounds for anticancer drug development

Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied beca...

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Vydáno v:Clinics (Sao Paulo)
Hlavní autoři: Paier, Carlos Roberto Koscky, Maranhão, Sarah Sant'Anna, Carneiro, Teiliane Rodrigues, Lima, Lídia Moreira, Rocha, Danilo Damasceno, da Silva Santos, Renan, de Farias, Kaio Moraes, de Moraes-Filho, Manoel Odorico, Pessoa, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018
Témata:
Review Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256996/
https://ncbi.nlm.nih.gov/pubmed/30540125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6061/clinics/2018/e813s
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