Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium

Cryptosporidium species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishes...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Bartelt, Luther A., Bolick, David T., Kolling, Glynis L., Stebbins, Erin, Huston, Christopher D., Guerrant, Richard L., Hoffman, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256802/
https://ncbi.nlm.nih.gov/pubmed/30297368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00718-18
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