Double-Blind, Randomized, Placebo-Controlled Phase II Dose-Finding Study To Evaluate High-Dose Rifampin for Tuberculous Meningitis

High doses of rifampin may help patients with tuberculous meningitis (TBM) to survive. Pharmacokinetic pharmacodynamic evaluations suggested that rifampin doses higher than 13 mg/kg given intravenously or 20 mg/kg given orally (as previously studied) are warranted to maximize treatment response. In...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Dian, S., Yunivita, V., Ganiem, A. R., Pramaesya, T., Chaidir, L., Wahyudi, K., Achmad, T. H., Colbers, A., te Brake, L., van Crevel, R., Ruslami, R., Aarnoutse, R.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Clinical Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256787/
https://ncbi.nlm.nih.gov/pubmed/30224533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01014-18
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