Population Pharmacokinetic Model and Limited Sampling Strategies for Personalized Dosing of Levofloxacin in Tuberculosis Patients

Levofloxacin is an antituberculosis drug with substantial interindividual pharmacokinetic variability; therapeutic drug monitoring (TDM) could therefore be helpful to improve treatment results. TDM would be more feasible with limited sampling strategies (LSSs), a method to estimate the area under th...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: van den Elsen, Simone H. J., Sturkenboom, Marieke G. G., van't Boveneind-Vrubleuskaya, Natasha, Skrahina, Alena, van der Werf, Tjip S., Heysell, Scott K., Mpagama, Stellah, Migliori, Giovanni B., Peloquin, Charles A., Touw, Daan J., Alffenaar, Jan-Willem C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Clinical Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256746/
https://ncbi.nlm.nih.gov/pubmed/30373800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01092-18
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