Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species

Anlotinib is a new oral tyrosine kinase inhibitor; this study was designed to characterize its pharmacokinetics and disposition. Anlotinib was evaluated in rats, tumor-bearing mice, and dogs and also assessed in vitro to characterize its pharmacokinetics and disposition and drug interaction potentia...

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Udgivet i:Acta Pharmacol Sin
Main Authors: Zhong, Chen-chun, Chen, Feng, Yang, Jun-ling, Jia, Wei-wei, Li, Li, Cheng, Chen, Du, Fei-fei, Zhang, Su-ping, Xie, Cheng-ying, Zhang, Na-ting, Olaleye, Olajide E, Wang, Feng-qing, Xu, Fang, Lou, Li-guang, Chen, Dong-ying, Niu, Wei, Li, Chuan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256268/
https://ncbi.nlm.nih.gov/pubmed/29620050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.199
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