ABCC10 Plays a Significant Role in the Transport of Gefitinib and Contributes to Acquired Resistance to Gefitinib in NSCLC

Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (EGFR-TKI), is used clinically as first-line therapy in patients with advanced non-small cell lung cancer (NSCLC) with EGFR activating mutations, but the inevitable development of acquired resistance limits its efficacy....

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Zhao, Hongbo, Huang, Yutang, Shi, Jingjing, Dai, Yi, Wu, Lanxiang, Zhou, Honghao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256088/
https://ncbi.nlm.nih.gov/pubmed/30515095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01312
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