Food‐effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers

AIMS: This study aimed to determine the effect of food intake on uracil and dihydrouracil plasma levels. These levels are a promising marker for dihydropyrimidine dehydrogenase activity and for individualizing fluoropyrimidine anticancer therapy. METHODS: A randomized, cross‐over study in 16 healthy...

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Publicat a:Br J Clin Pharmacol
Autors principals: Henricks, Linda M., Jacobs, Bart A. W., Meulendijks, Didier, Pluim, Dick, van den Broek, Daan, de Vries, Niels, Rosing, Hilde, Beijnen, Jos H., Huitema, Alwin D. R., Guchelaar, Henk‐Jan, Cats, Annemieke, Schellens, Jan H. M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256055/
https://ncbi.nlm.nih.gov/pubmed/30047584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13719
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