Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real‐world cohort study: does age matter?

AIM: Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and <70 years) in clinical practice. METHODS: KI plasma concentra...

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Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Crombag, Marie‐Rose B.S., van Doremalen, Jacobine G.C., Janssen, Julie M., Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H., Steeghs, Neeltje, Huitema, Alwin D.R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256014/
https://ncbi.nlm.nih.gov/pubmed/30068020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13725
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