Opposing Effects on Vascular Smooth Muscle Cell Proliferation and Macrophage-induced Inflammation Reveal a Protective Role for the Proresolving Lipid Mediator Receptor ChemR23 in Intimal Hyperplasia

Intimal hyperplasia remains a significant clinical problem in for example coronary artery bypass graft failure. Since omega-3 fatty acids reduce intimal hyperplasia, we hypothesized that the G protein-coupled receptor ChemR23 for the omega-3-derived pro-resolving lipid mediator resolvin E1 drives th...

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Vydáno v:Front Pharmacol
Hlavní autoři: Artiach, Gonzalo, Carracedo, Miguel, Clària, Joan, Laguna-Fernandez, Andres, Bäck, Magnus
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255922/
https://ncbi.nlm.nih.gov/pubmed/30515096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01327
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