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Asymmetric Friedel-Crafts Alkylation of Indole with Chalcones Catalyzed by Chiral Phosphoric Acids

The reaction of indole with chalcones, to give Michael-type adducts, was found to occur with good efficiency (up to 98% yield) and moderate enantioselectivity (up to 52% e.e.) in the presence of a chiral BINOL-based phosphoric acid. Furthermore, the alkylation products can be obtained in much higher...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Molecules
Egile Nagusiak: Scettri, Arrigo, Villano, Rosaria, Acocella, Maria Rosaria
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Molecular Diversity Preservation International 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255435/
https://ncbi.nlm.nih.gov/pubmed/19701143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules14083030
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