Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH

The effects of the growth hormone-releasing hormone (GHRH) agonist MR409 on various human cancer cells were investigated. In H446 small cell lung cancer (SCLC) and HCC827 and H460 (non-SCLC) cells, MR409 promoted cell viability, reduced cell apoptosis, and induced the production of cellular cAMP in...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Schally, Andrew V., Wang, Haibo, He, Jinlin, Cai, Renzhi, Sha, Wei, Popovics, Petra, Perez, Roberto, Vidaurre, Irving, Zhang, Xianyang
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255156/
https://ncbi.nlm.nih.gov/pubmed/30373845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813375115
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