Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation

Nimbolide is considered a promising natural product in cancer prevention and treatment. However, it is not known yet, whether the different mechanisms of multidrug resistance (MDR) influence its anticancer activity. In this study, well-known MDR mechanisms (ABCB1, ABCG2, ABCB5, TP53, EGFR) were eval...

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Vydáno v:Oncotarget
Hlavní autoři: Mahmoud, Nuha, Saeed, Mohamed E.M., Sugimoto, Yoshikazu, Klauck, Sabine M., Greten, Henry J., Efferth, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254660/
https://ncbi.nlm.nih.gov/pubmed/30515268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26299
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