Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR)

Betulinic acid (BetA) is a naturally occurring pentacyclic triterpene isolated from the outer bark of white-barked birch trees and many other medicinal plants. Here, we studied betulinic acid's cytotoxic activity against drug-resistant tumor cell lines. P-glycoprotein (MDR1/ABCB1) and BCRP (ABC...

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Vydáno v:Front Pharmacol
Hlavní autoři: Saeed, Mohamed E. M., Mahmoud, Nuha, Sugimoto, Yoshikazu, Efferth, Thomas, Abdel-Aziz, Heba
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5962668/
https://ncbi.nlm.nih.gov/pubmed/29867487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00481
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