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The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains

In order to proliferate and mount an infection, many bacterial pathogens need to acquire iron from their host. The most abundant iron source in the body is the oxygen transporter hemoglobin (Hb). Streptococcus pyogenes, a potentially lethal human pathogen, uses the Shr protein to capture Hb on the c...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Macdonald, Ramsay, Cascio, Duilio, Collazo, Michael J., Phillips, Martin, Clubb, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254355/
https://ncbi.nlm.nih.gov/pubmed/30301765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005261
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