994. AS03-Adjuvanted H5N1 Avian Influenza Vaccine Modulates Early Innate Immune Signatures in Peripheral Blood Mononuclear Cells

BACKGROUND: Influenza A/H5N1 vaccines have been poorly immunogenic. Addition of Adjuvant System 03 (AS03) markedly enhances immune responses, but the mechanisms of this enhancement are unclear. METHODS: We compared gene expression in peripheral blood mononuclear cells (PBMCs) between recipients of A...

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Publicado no:Open Forum Infect Dis
Main Authors: Howard, Leigh, Goll, Johannes, Jensen, Travis, Hill, Heather, Gelber, Casey, Creech, C Buddy, Edwards, Kathryn
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254069/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.831
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