Cell-Based Systems Biology Analysis of Human AS03-Adjuvanted H5N1 Avian Influenza Vaccine Responses: A Phase I Randomized Controlled Trial

BACKGROUND: Vaccine development for influenza A/H5N1 is an important public health priority, but H5N1 vaccines are less immunogenic than seasonal influenza vaccines. Adjuvant System 03 (AS03) markedly enhances immune responses to H5N1 vaccine antigens, but the underlying molecular mechanisms are inc...

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Publicado en:PLoS One
Autores principales: Howard, Leigh M., Hoek, Kristen L., Goll, Johannes B., Samir, Parimal, Galassie, Allison, Allos, Tara M., Niu, Xinnan, Gordy, Laura E., Creech, C. Buddy, Prasad, Nripesh, Jensen, Travis L., Hill, Heather, Levy, Shawn E., Joyce, Sebastian, Link, Andrew J., Edwards, Kathryn M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242433/
https://ncbi.nlm.nih.gov/pubmed/28099485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167488
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