Simultaneous population pharmacokinetic modelling of plasma and intracellular PBMC miltefosine concentrations in New World cutaneous leishmaniasis and exploration of exposure–response relationships

OBJECTIVES: Leishmania parasites reside within macrophages and the direct target of antileishmanial drugs is therefore intracellular. We aimed to characterize the intracellular PBMC miltefosine kinetics by developing a population pharmacokinetic (PK) model simultaneously describing plasma and intrac...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Kip, Anke E, Castro, María del Mar, Gomez, Maria Adelaida, Cossio, Alexandra, Schellens, Jan H M, Beijnen, Jos H, Saravia, Nancy Gore, Dorlo, Thomas P C
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251527/
https://ncbi.nlm.nih.gov/pubmed/29757380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky143
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