Disordered Peptides Looking for Their Native Environment: Structural Basis of CB1 Endocannabinoid Receptor Binding to Pepcans

Endocannabinoid peptides, or “pepcans,” are endogenous ligands of the CB1 cannabinoid receptor. Depending on their length, they display diverse activity: For instance, the nona-peptide Pepcan-9, also known as hemopressin, is a powerful inhibitor of CB1, whereas the longer variant Pepcan-12, which ex...

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Détails bibliographiques
Publié dans:Front Mol Biosci
Auteurs principaux: Emendato, Alessandro, Guerrini, Remo, Marzola, Erika, Wienk, Hans, Boelens, Rolf, Leone, Serena, Picone, Delia
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Molecular Biosciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250848/
https://ncbi.nlm.nih.gov/pubmed/30505835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2018.00100
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