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Engineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance
Fc domain fusion can improve the therapeutic effects of relatively small biological molecules such as peptides, cytokines, and antibody fragments. Fc fusion proteins can also be used to enhance the cytotoxic effects of small bispecific antibodies (bsAbs). However, fragmentation of Fc fusion proteins...
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| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6250740/ https://ncbi.nlm.nih.gov/pubmed/30467410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35489-y |
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