In-depth validation of total HIV-1 DNA assays for quantification of various HIV-1 subtypes

HIV-1 DNA quantification serves as an important reservoir biomarker in HIV cure trials. However, the high genetic diversity of HIV-1 represented by different subtypes may bring inaccuracy in quantifying HIV-1 DNA and a sensitive and validated assay covering diverse HIV-1 subtypes is lacking. Therefo...

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Published in:Sci Rep
Main Authors: Rutsaert, Sofie, De Spiegelaere, Ward, Van Hecke, Clarissa, De Scheerder, Marie-Angélique, Kiselinova, Maja, Vervisch, Karen, Trypsteen, Wim, Vandekerckhove, Linos
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250682/
https://ncbi.nlm.nih.gov/pubmed/30467426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35403-6
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