Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema

BACKGROUND: Mitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) and other stimuli. We examined the importance of mtROS and NLRP3 inflammasome and their int...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Li, Feng, Xu, Mengmeng, Wang, Muyun, Wang, Lei, Wang, Hanying, Zhang, Hai, Chen, Yuqing, Gong, Jicheng, Zhang, Junfeng(Jim), Adcock, Ian M., Chung, Kian Fan, Zhou, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249848/
https://ncbi.nlm.nih.gov/pubmed/30466433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-018-0931-8
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