Prospective Study of Cancer Genetic Variants: Variation in Rate of Reclassification by Ancestry

BACKGROUND: In germline genetic testing, variants from understudied ancestries have been disproportionately classified as being of uncertain significance. We hypothesized that the rate of variant reclassification likewise differs by ancestry. METHODS: Nonbenign variants in actionable genes were coll...

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Pubblicato in:J Natl Cancer Inst
Autori principali: Slavin, Thomas P, Van Tongeren, Lily R, Behrendt, Carolyn E, Solomon, Ilana, Rybak, Christina, Nehoray, Bita, Kuzmich, Lili, Niell-Swiller, Mariana, Blazer, Kathleen R, Tao, Shu, Yang, Kai, Culver, Julie O, Sand, Sharon, Castillo, Danielle, Herzog, Josef, Gray, Stacy W, Weitzel, Jeffrey N
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249694/
https://ncbi.nlm.nih.gov/pubmed/29618041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djy027
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