Implementing tumor mutational burden (TMB) analysis in routine diagnostics—a primer for molecular pathologists and clinicians

Tumor mutational burden (TMB) is a new biomarker for prediction of response to PD-(L)1 treatment. Comprehensive sequencing approaches (i.e., whole exome and whole genome sequencing) are ideally suited to measure TMB directly. However, as their applicability in routine diagnostics is currently limite...

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Bibliografische gegevens
Gepubliceerd in:Transl Lung Cancer Res
Hoofdauteurs: Allgäuer, Michael, Budczies, Jan, Christopoulos, Petros, Endris, Volker, Lier, Amelie, Rempel, Eugen, Volckmar, Anna-Lena, Kirchner, Martina, von Winterfeld, Moritz, Leichsenring, Jonas, Neumann, Olaf, Fröhling, Stefan, Penzel, Roland, Thomas, Michael, Schirmacher, Peter, Stenzinger, Albrecht
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AME Publishing Company 2018
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Review Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249620/
https://ncbi.nlm.nih.gov/pubmed/30505715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tlcr.2018.08.14
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