Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report

BACKGROUND: Inhibition of the oncogenic fusion-gene EML4-ALK is a current first-line approach for patients with stage IV non-small cell lung cancer. While FISH was established as the gold standard for identifying these patients, there is accumulating evidence that other methods of detection, i.e., i...

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Detalhes bibliográficos
Publicado no:Diagn Pathol
Main Authors: Volckmar, Anna-Lena, Endris, Volker, Bozorgmehr, Farastuk, Lier, Clemens, Porcel, Carlota, Kirchner, Martina, Leichsenring, Jonas, Penzel, Roland, Thomas, Michael, Schirmacher, Peter, Warth, Arne, Stenzinger, Albrecht
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116222/
https://ncbi.nlm.nih.gov/pubmed/27863497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-016-0581-4
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