Scrophularia Atropatana Extract Reverses TP53 Gene Promoter Hypermethylation and Decreases Survivin Antiapoptotic Gene Expression in Breast Cancer Cells

BACKGROUND: In many cases of breast cancer, the aberrant methylation of TP53 gene leads to uncontrolled cell proliferation and apoptosis inhibition. Moreover, expression of oncogenes which are under the control of P53 protein could be altered. Survivin as a conspicuous example of this category plays...

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Veröffentlicht in:Asian Pac J Cancer Prev
Hauptverfasser: Fakhr, Mehrdad Ghavifekr, Kahkhaie, Kolsoum Rezaie, Shanehbandi, Dariush, Hagh, Majid Farshdousti, Zarredar, Habib, Safarzadeh, Elham, Vind, Mina Abdolrahimi, Baradaran, Behzad
Format: Artigo
Sprache:Inglês
Veröffentlicht: West Asia Organization for Cancer Prevention 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249477/
https://ncbi.nlm.nih.gov/pubmed/30256066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22034/APJCP.2018.19.9.2599
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