USP10 Is a Driver of Ubiquitinated Protein Aggregation and Aggresome Formation to Inhibit Apoptosis

Accumulation of ubiquitinated proteins is cytotoxic, but cells inactivate these cytotoxicities by inducing aggresome formation. We found that ubiquitin-specific protease 10 (USP10) inhibits ubiquitinated protein-induced apoptosis by inducing aggresome formation. USP10 interacted with the ubiquitin r...

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Udgivet i:iScience
Main Authors: Takahashi, Masahiko, Kitaura, Hiroki, Kakita, Akiyoshi, Kakihana, Taichi, Katsuragi, Yoshinori, Nameta, Masaaki, Zhang, Lu, Iwakura, Yuriko, Nawa, Hiroyuki, Higuchi, Masaya, Komatsu, Masaaki, Fujii, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249355/
https://ncbi.nlm.nih.gov/pubmed/30469013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.11.006
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