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Sub-Picomolar Inhibition of HIV-1 Protease with a Boronic Acid
Boronic acids have been typecast as moieties for covalent complexation and are employed only rarely as agents for noncovalent recognition. By exploiting the profuse ability of a boronic acid group to form hydrogen bonds, we have developed an inhibitor of HIV-1 protease with extraordinary affinity. S...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6249028/ https://ncbi.nlm.nih.gov/pubmed/30346745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b07366 |
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