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Improving SNP prioritization and pleiotropic architecture estimation by incorporating prior knowledge using graph-GPA

SUMMARY: Integration of genetic studies for multiple phenotypes is a powerful approach to improving the identification of genetic variants associated with complex traits. Although it has been shown that leveraging shared genetic basis among phenotypes, namely pleiotropy, can increase statistical pow...

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Detalles Bibliográficos
Publicado en:Bioinformatics
Main Authors: Kim, Hang J, Yu, Zhenning, Lawson, Andrew, Zhao, Hongyu, Chung, Dongjun
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248798/
https://ncbi.nlm.nih.gov/pubmed/29432514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty061
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