Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

IMPORTANCE: Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele is strongly associated with β-amyloid (Aβ) aggregation and risk of AD, but its association with TD...

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Vydáno v:JAMA Neurol
Hlavní autoři: Wennberg, Alexandra M., Tosakulwong, Nirubol, Lesnick, Timothy G., Murray, Melissa E., Whitwell, Jennifer L., Liesinger, Amanda M., Petrucelli, Leonard, Boeve, Bradley F., Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Dickson, Dennis W., Josephs, Keith A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2018
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248121/
https://ncbi.nlm.nih.gov/pubmed/30422173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2018.3139
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