Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings

BACKGROUND: Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer phenotypes, including human epidermal growth factor receptor-2 (HER2)-positive disease. Since JAM-A has been described to regulate HER2 ex...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Leech, Astrid O., Vellanki, Sri HariKrishna, Rutherford, Emily J., Keogh, Aoife, Jahns, Hanne, Hudson, Lance, O’Donovan, Norma, Sabri, Siham, Abdulkarim, Bassam, Sheehan, Katherine M., Kay, Elaine W., Young, Leonie S., Hill, Arnold D. K., Smith, Yvonne E., Hopkins, Ann M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247757/
https://ncbi.nlm.nih.gov/pubmed/30458861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-1064-1
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