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Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2

Phosphoinositides are essential signaling lipids that play a critical role in regulating ion channels, and their dysregulation often results in fatal diseases including cardiac arrhythmia and paralysis. Despite decades of intensive research, the underlying molecular mechanism of lipid agonism and sp...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Meng, Xuan-Yu, Kang, Seung-gu, Zhou, Ruhong
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247517/
https://ncbi.nlm.nih.gov/pubmed/30542582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01284a
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