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Molecular mechanism of phosphoinositides' specificity for the inwardly rectifying potassium channel Kir2.2

Phosphoinositides are essential signaling lipids that play a critical role in regulating ion channels, and their dysregulation often results in fatal diseases including cardiac arrhythmia and paralysis. Despite decades of intensive research, the underlying molecular mechanism of lipid agonism and sp...

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Библиографические подробности
Опубликовано в: :Chem Sci
Главные авторы: Meng, Xuan-Yu, Kang, Seung-gu, Zhou, Ruhong
Формат: Artigo
Язык:Inglês
Опубликовано: Royal Society of Chemistry 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247517/
https://ncbi.nlm.nih.gov/pubmed/30542582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc01284a
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