Impaired development and expansion of germinal center follicular T helper cells in SIV-infected neonatal macaques

Germinal center follicular CD4+ T helper (GC Tfh) cells are critical for cognate B-cell help in humoral immune responses to pathogenic infections. Although Tfh cells are expanded or depleted in HIV/SIV-infected adults, the effects of pediatric HIV/SIV infection on Tfh cells remain unclear. Here we e...

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Udgivet i:J Immunol
Main Authors: Xu, Huanbin, Ziani, Widade, Shao, Jiasheng, Doyle-Meyers, Lara A., Russell-Lodrigue, Kasi E., Ratterree, Marion, Veazey, Ronald S., Wang, Xiaolei
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245642/
https://ncbi.nlm.nih.gov/pubmed/30104244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800235
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