Species-Specific Transcriptional Regulation of Genes Involved in Nitric Oxide Production and Arginine Metabolism in Macrophages

Activated mouse macrophages metabolize arginine via NO synthase (NOS2) to produce NO as an antimicrobial effector. Published gene expression datasets provide little support for the activation of this pathway in human macrophages. Generation of NO requires the coordinated regulation of multiple genes...

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Publicado no:Immunohorizons
Main Authors: Young, Rachel, Bush, Stephen J., Lefevre, Lucas, McCulloch, Mary E. B., Lisowski, Zofia M., Muriuki, Charity, Waddell, Lindsey A., Sauter, Kristin A., Pridans, Clare, Clark, Emily L., Hume, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245571/
https://ncbi.nlm.nih.gov/pubmed/30467554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1700073
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