CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet

In clinical trials, inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels but does not robustly improve cardiovascular outcomes. Approximately two-thirds of trial participants are obese. Lower plasma CETP activity is associated with increased cardiovascular risk in hu...

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Veröffentlicht in:Diabetes
Hauptverfasser: Zhu, Lin, Luu, Thao, Emfinger, Christopher H., Parks, Bryan A., Shi, Jeanne, Trefts, Elijah, Zeng, Fenghua, Kuklenyik, Zsuzsanna, Harris, Raymond C., Wasserman, David H., Fazio, Sergio, Stafford, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2018
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245220/
https://ncbi.nlm.nih.gov/pubmed/30213825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0474
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