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Effects of Anonaine on Dopamine Biosynthesis and l-DOPA-Induced Cytotoxicity in PC12 Cells
The effects of anonaine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells were investigated. Anonaine at concentration ranges of 0.01-0.2 μM showed a significant inhibition of dopamine content at 24 h, with an IC(50) value of 0.05 μM. Anonain...
Guardat en:
| Publicat a: | Molecules |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6245076/ https://ncbi.nlm.nih.gov/pubmed/18305432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules13020475 |
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