Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol

As a catechol isoquinoline, salsolinol (Sal) is widely distributed in mammalian brains, and is increased in the cerebrospinal fluid (CSF) and urine of Parkinsonian patients. Sal can be metabolized to N-methyl-salsolinol (NM-Sal), an MPP+-like neurotoxin, and impairs the function of dopaminergic neur...

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Detalhes bibliográficos
Main Authors: Qianqian Xiong, Xiaotong Zheng, Jianan Wang, Zixuan Chen, Yulin Deng, Rugang Zhong, Juan Wang, Xuechai Chen
Formato: Artigo
Idioma:Inglês
Publicado em: IMR Press 2022-03-01
Colecção:Journal of Integrative Neuroscience
Assuntos:
sal synthase
parkinson's disease
pc12 cells
salsolinol
n-methyl-salsolinol
mitochondrial membrane potential
apoptosis
Acesso em linha:https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102071
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