Effects of a Dehydroevodiamine-Derivative on Synaptic Destabilization and Memory Impairment in the 5xFAD, Alzheimer's Disease Mouse Model

Carboxy-dehydroevodiamine·HCl (cx-DHED) is a derivative of DHED, which improves memory impairment. Carboxyl modification increases solubility in water, indicating that its bioavailability is higher than that of DHED. Cx-DHED is expected to have better therapeutic effects on Alzheimer's disease...

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Bibliografske podrobnosti
izdano v:Front Behav Neurosci
Main Authors: Kang, Shinwoo, Ha, Sungji, Park, Hyunjun, Nam, Eunjoo, Suh, Won Hyuk, Suh, Yoo-Hun, Chang, Keun-A
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243640/
https://ncbi.nlm.nih.gov/pubmed/30483077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2018.00273
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