Cell-autonomous requirement of TDP-43, an ALS/FTD signature protein, for oligodendrocyte survival and myelination

TDP-43 aggregates in neurons and glia are the defining pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), raising the possibility of glial damage in the disease pathogenesis. However, the normal physiological functions of TDP-43 in glia are largely unknow...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Wang, Jia, Ho, Wan Yun, Lim, Kenneth, Feng, Jia, Tucker-Kellogg, Greg, Nave, Klaus-Armin, Ling, Shuo-Chien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2018
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243235/
https://ncbi.nlm.nih.gov/pubmed/30373824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809821115
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