Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction

Cytotoxic chemotherapy, still the most widely adopted anticancer treatment, aims at eliminating cancer cells inducing apoptosis with DNA damaging agents, exploiting the differential replication rate of cancer vs. normal cells; efficiency is evaluated in terms of extent of induced apoptosis, which de...

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Vydáno v:Front Pharmacol
Hlavní autoři: Bruni, Emanuele, Reichle, Albrecht, Scimeca, Manuel, Bonanno, Elena, Ghibelli, Lina
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243040/
https://ncbi.nlm.nih.gov/pubmed/30483138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01307
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