Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction

Cytotoxic chemotherapy, still the most widely adopted anticancer treatment, aims at eliminating cancer cells inducing apoptosis with DNA damaging agents, exploiting the differential replication rate of cancer vs. normal cells; efficiency is evaluated in terms of extent of induced apoptosis, which de...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Principais autores: Bruni, Emanuele, Reichle, Albrecht, Scimeca, Manuel, Bonanno, Elena, Ghibelli, Lina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243040/
https://ncbi.nlm.nih.gov/pubmed/30483138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01307
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