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Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain

Kainate-type glutamate receptors play critical roles in excitatory synaptic transmission and synaptic plasticity in the brain. GluK1 and GluK2 possess fundamentally different capabilities in surface trafficking as well as synaptic targeting in hippocampal CA1 neurons. Here we find that the excitator...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Duan, Gui-Fang, Ye, Yaxin, Xu, Sha, Tao, Wucheng, Zhao, Shiping, Jin, Tengchuan, Nicoll, Roger A., Shi, Yun Stone, Sheng, Nengyin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242971/
https://ncbi.nlm.nih.gov/pubmed/30451858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07403-7
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