Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker

Prediction of lung cancer metastasis relies on post-resection assessment of tumor histology, which is a severe limitation since only a minority of lung cancer patients are diagnosed with resectable disease. Therefore, characterization of metastasis-predicting biomarkers in pre-resection small biopsy...

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Vydáno v:PLoS One
Hlavní autoři: Pérez-Morales, Jaileene, Mejías-Morales, Darielys, Rivera-Rivera, Stephanie, González-Flores, Jonathan, González-Loperena, Mónica, Cordero-Báez, Fernando Y., Pedreira-García, Wilfredo M., Chardón-Colón, Camille, Cabán-Rivera, Jennifer, Cress, W. Douglas, Gordian, Edna R., Muñoz-Antonia, Teresita, Cabrera-Ríos, Mauricio, Isidro, Angel, Coppola, Domenico, Rosa, Marilin, Boyle, Theresa A., Izumi, Victoria, Koomen, John M., Santiago-Cardona, Pedro G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242691/
https://ncbi.nlm.nih.gov/pubmed/30452490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207483
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